Penn State vs. Ohio odds, prediction, line: 2022 Week 2 college football picks from model on 48-37 run – CBS Sports

  • September 11, 2022

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Teams looking to start the season 2-0 meet when the Ohio Bobcats face the Penn State Nittany Lions in a non-conference matchup on Saturday at University Park, Pa. The Nittany Lions (1-0) rallied in the last minute to defeat Purdue 35-31 in their opener, while the Bobcats (1-0) staved off a late rally to knock off Florida Atlantic 41-38. This will be the first meeting between the schools since 2012, a 24-14 Ohio win. Penn State, however, holds a 5-1 edge in the all-time series.
Kickoff from Beaver Stadium is set for noon ET. Ohio was 86th in the nation in total offense last season, averaging 371.4 yards per game, while Penn State was 82nd nationally at 376.4. The Nittany Lions are favored by 27.5 points in the latest Ohio vs. Penn State odds from Caesars Sportsbook, while the over-under for total points scored is 54. Before making any Penn State vs. Ohio picks, check out the college football predictions and betting advice from the SportsLine Projection Model.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Ohio vs. Penn State and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Here are several college football odds and betting lines and for Penn State vs. Ohio:
The Nittany Lions are led by fifth-year senior quarterback Sean Clifford, who has played in 39 career games, making 34 starts. Against Purdue, he became just the third quarterback in program history to have started a game in four different seasons, joining Zack Mills (2001-04) and Tony Sacca (1988-92). Clifford earned Big Ten Co-Offensive Player of the Week honors following his performance at Purdue. In that game, he registered 282 passing yards and tied a career high with four touchdowns passes.
Sophomore Keyvone Lee leads Penn State’s stable of running backs. In 2021, Lee rushed for 530 yards on 108 carries (4.9 average), and has 998 career rushing yards (4.8 average) and six touchdowns. He also has 29 receptions for 211 yards and a score. Against Purdue last week, Lee caught what proved to be the game-winning 10-yard touchdown reception with 57 seconds to go. He is a member of the Doak Walker Award watch list.
Redshirt junior Kurtis Rourke had a personal record-setting performance in the Week 1 win for the Bobcats. Rourke set two career highs when he threw for 345 yards and four touchdowns, bettering his previous marks of 308 yards and three TDs. He also added one rushing score. For his career, he has completed 228 of 339 passes (67.3 percent) for 2,548 yards and 18 TDs. He has been intercepted seven times.
Defensively, junior safety Ben Johnson had a monster day against Florida Atlantic with 15 tackles, including five solo. He nearly equaled his totals from last season when he registered 21 tackles, including nine solo in 11 games. In his career, he has made 44 tackles, including 19 solo.
SportsLine’s model is leaning Over on the point total. In fact, it says Ohio running back Sieh Bangura will rush for more than 100 yards and a score, while Penn State quarterback Sean Clifford passes for more than 330 yards and three touchdowns. It has also generated an against-the-spread pick that cashes in almost 70% of simulations. You can only get the model’s Penn State vs. Ohio pick at SportsLine
So who wins Ohio vs. Penn State? And which side of the spread cashes in almost 70% of simulations?  Visit SportsLine now to see which side of the Ohio vs. Penn State spread to jump on, all from the advanced model that finished the past six-plus years up nearly $3,600 on its FBS college football picks, and find out.
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