It will leave Aaron Danks in charge, who will likely revert to the standard 4-3-3 to give his team the best possible chance to beat the buoyant Bees.
They have only lost twice in their last eight Premier League fixtures, and sit in a respectable tenth.
The Midlands outfit will have their work cut out to get anything from this well-oiled machine, but with suspensions and poor performances, there is plenty of decisions for the caretaker manager to consider.
Danks can be expected to make just three changes from the side that were pulverised by Fulham.
Emiliano Martinez will continue just behind an unchanged defence that has leaked 16 goals in just 11 games. Matty Cash will be hoping to find his form of old once again on the right flank.
Summer signing Leander Dendoncker will also notch his first start in central midfield. He has made just four cameo appearances for his new club and has only been involved in one win.
The £90k-per-week Belgian had impressed for his old club Wolverhampton Wanderers, and will be looking to find some form that saw Nuno Espirito Santo dub him a “top player“.
He will sit alongside Villa captain John McGinn, with Jacob Ramsey retaining his place despite his abysmal performance against the Cottagers.
Leon Bailey will surely drop to the bench after a similarly terrible display. The Jamaican is running low on chances now and will have to work hard to impress whoever the new manager may be. Emiliano Buendia will be his replacement.
The opposite flank will see another underwhelming star return, in the hopes that he can summon a moment of magic to help them snatch an unlikely win. Philippe Coutinho will start in place of Ollie Watkins, who will move to the central striker position.
Danny Ings will once again drop to the bench, after failing to impress in another league appearance.
Predicted Aston Villa XI: Martinez; Cash, Konsa, Mings, Young; McGinn, Dendoncker, Ramsey; Buendia, Coutinho, Watkins.
Click here to comment on this article
Give us feedback on your Football FanCast experience